Every year a distinguished mathematician is appointed as a visiting professor at the Mathematical Institute for a few months, the so-called Kloosterman chair. The chair is named after Hendrik Douwe Kloosterman (1900-1968). In 2019 professor Mark Alber (University of California, Riverside) was appointed as Kloosterman professor. This year, he is once again the guest of professor Roeland Merks of the Mathematical Institute (this time with a Fulbright US Scholar Fellowship) and will deliver the accompanying lecture.

Hendrik Douwe Kloosterman (Rottevalle, 9 April 1900 - Leiden, 6 May 1968) studied in Leiden, Copenhagen, Oxford, Göttingen and Hamburg. In 1930 he returned to Leiden as lector and became full professor in 1947. He is mostly known for his work in analytic number theory on what we now call 'Kloosterman sums'. Read more.

Lecture

The title of the Kloosterman lecture of 2024 is 

Digital twin of blood clotting and thrombosis: mathematical and computational challenges

Summary:

Thromboembolism, one of the leading causes of morbidity and mortality worldwide, is characterized by formation of obstructive intravascular clots (thrombi) and their mechanical breakage (embolization). Mechanical stability of intravascular blood clots determines the effectiveness of stemming bleeding (haemostasis) at the sites of vessel injury and the course and outcomes of pathological blood vessel obstruction (thrombosis). Dislodged pieces (emboli) of clots can result in occlusion of downstream blood vessels in lungs or brain, leading to life-threatening complications, such as pulmonary embolism or ischaemic stroke, respectively. Thus, the ability to evaluate and predict the mechanical stability of a blood clot under deformation, contraction and different flow conditions is necessary for evaluation of the risk of thromboembolism. Our group introduced several novel mathematical and computational patient specific modes of clotting (digital twin) including a multi-phase model that describes active interactions between the main components of the clot, including platelets and fibrin, to study the impact of various patient specific physiologically relevant blood shear flow conditions on deformation and embolization of a partially obstructive clot.

> Arjen Doelman: “Mark gives great presentations and is exceptionally strong in communicating with colleagues in fields outside mathematics. He shows how powerful mathematics can be in the context of other scientific areas. Therefore, his talk will also be interesting and relevant for many of our colleagues in our faculty.”

Information

The lecture will be in English. After the lecture, a reception will be organised in De Fusie. For questions, please contact Arjen Doelman.

Register

Please register beforehand for the lecture and/or reception. Everyone interested is welcome to join.